Abstract
AbstractGout is a common arthritis condition due to disorders of purine metabolism and decreased uric acid excretion. Although researchers have carried out various studies on this disease, there are no effective drugs for patients with gout. In traditional Chinese medicine (TCM), gout pertains the category of Bi pattern due to qi stagnation in the meridians and collaterals. Chinese herbal medicinals has been employed to treat Bi patterns since the ancient China. In recent decades, classical TCM formulas and agents isolated from some Chinese herbal medicinals have been applied to treat gout and have achieved satisfactory effect. In this review, we focus on recent studies of gout in which TCM formulas were applied to treat animal models or to treat patients, and summarize the mechanism of gout from TCM perspective, the clinical application, pharmacological mechanism and the chemical compounds of TCM formulas in treating gout. In conclusion, through this study, we summarized the application principle of TCM formulas in gout treatment and some key issues of current research, and we hope this study will provide some references for applying TCM formulas to treat gout and will lay a foundation for the development of novel formulas for gout treatments.
Funder
National Nature Science Foundation of China
Shandong Education Science Plan
Publisher
Springer Science and Business Media LLC
Subject
Complementary and alternative medicine,Pharmacology
Reference75 articles.
1. Zeng XF, Chen YL. 2016 China gout diagnosis and treatment guide. Zhejiang Med J. 2017;39(21):1823–32.
2. Yu KH, Chen DY, Chen JH, Chen SY, Chen SM, Cheng TT, et al. Management of gout and hyperuricemia: multidisciplinary consensus in Taiwan. Int J Rheum Dis. 2018;21(4):772–87.
3. Jiang Y, Lin Y, Hu YJ, Song XJ, Pan HH, Zhang HJ. Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd, Ameliorates hyperuricemia and acute gouty arthritis in animal model. BMC Complement Altern Med. 2017;17(1):320.
4. Sivera F, Wechalekar MD, Andres M, Buchbinder R, Carmona L. Interleukin-1 inhibitors for acute gout. Cochrane Database Syst Rev. 2014;9:Cd009993.
5. Xiao N, Chen H, He SY, Xue CX, Sui H, Chen J, et al. Evaluating the efficacy and adverse effects of clearing heat and removing dampness method of traditional Chinese medicine by comparison with western medicine in patients with gout. Evid Based Complement Alternat Med. 2018;2018:8591349.
Cited by
56 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献