Emerging applications of single-cell profiling in precision medicine of atherosclerosis

Author:

Lin Huiling,Zhang Ming,Hu Mi,Zhang Yangkai,Jiang WeiWei,Tang Wanying,Ouyang Yuxin,Jiang Liping,Mi Yali,Chen Zhi,He Pingping,Zhao Guojun,Ouyang XinpingORCID

Abstract

AbstractAtherosclerosis is a chronic, progressive, inflammatory disease that occurs in the arterial wall. Despite recent advancements in treatment aimed at improving efficacy and prolonging survival, atherosclerosis remains largely incurable. In this review, we discuss emerging single-cell sequencing techniques and their novel insights into atherosclerosis. We provide examples of single-cell profiling studies that reveal phenotypic characteristics of atherosclerosis plaques, blood, liver, and the intestinal tract. Additionally, we highlight the potential clinical applications of single-cell analysis and propose that combining this approach with other techniques can facilitate early diagnosis and treatment, leading to more accurate medical interventions.

Funder

Natural Science Foundation of China

Natural Science Foundation of Hunan Province

Chunhui Project Foundation of the Education Department of China

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

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