The effects of phosphodiesterase-5 inhibitor sildenafil against post-resuscitation myocardial and intestinal microcirculatory dysfunction by attenuating apoptosis and regulating microRNAs expression: essential role of nitric oxide syntheses signaling

Author:

Zhang Qian,Wang Guoxing,Yuan Wei,Wu Junyuan,Wang Miaomiao,Li ChunSheng

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference40 articles.

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2. Neumar RW, Nolan JP, Adrie C, Aibiki M, Berg RA (2008) Post-cardiac arrest syndrome epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, Inter-American Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 118:2452–2483

3. DE Choi, Jeong JY, Lim BJ, Chung S, Chang YK, Lee SJ (2009) Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats. Am J Physiol Renal Physiol 297:F362–F370

4. Loganathan S, Radovits T, Hirschberg K, Korkmaz S, Barnucz E, Karck M (2008) Effects of selective phosphodiesterase-5-inhibition on myocardial contractility and reperfusion injury after heart transplantation. Transplantation 86:1414–1418

5. Zhang Q, Yuan W, Wang G, Wu J, Wang M, Li C (2014) The protective effects of phosphodiesterase-5 inhibitor, sildenafil on post-resuscitation cardiac dysfunction of cardiac arrest: metabolic evidence from microdialysis. Crit Care 18(6):641 (Epub ahead of print)

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