Mechanism and treatment of olfactory dysfunction caused by coronavirus disease 2019

Author:

Hu Bian,Gong Mengdan,Xiang Yizhen,Qu Siyuan,Zhu Hai,Ye DongORCID

Abstract

AbstractCoronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the start of the pandemic, olfactory dysfunction (OD) has been reported as a common symptom of COVID-19. In some asymptomatic carriers, OD is often the first and even the only symptom. At the same time, persistent OD is also a long-term sequela seen after COVID-19 that can have a serious impact on the quality of life of patients. However, the pathogenesis of post-COVID-19 OD is still unclear, and there is no specific treatment for its patients. The aim of this paper was to review the research on OD caused by SARS-CoV-2 infection and to summarize the mechanism of action, the pathogenesis, and current treatments.

Funder

Ningbo Clinical Research Center for Otolaryngology Head and Neck Disease

the Ningbo “Technology Innovation 2025” Major Special Project

Ningbo Natural Science Foundation

Natural Science Foundation of Zhejiang Province

Ningbo Health Branding Subject Fund

Key Project of Huili Foundation

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

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