Abstract
AbstractFibrosis, a process caused by excessive deposition of extracellular matrix (ECM), is a common cause and outcome of organ failure and even death. Researchers have made many efforts to understand the mechanism of fibrogenesis and to develop therapeutic strategies; yet, the outcome remains unsatisfactory. In recent years, advances in epigenetics, including chromatin remodeling, histone modification, DNA methylation, and noncoding RNA (ncRNA), have provided more insights into the fibrotic process and have suggested the possibility of novel therapy for organ fibrosis. In this review, we summarize the current research on the epigenetic mechanisms involved in organ fibrosis and their possible clinical applications.
Graphical Abstract
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
The Fund for Excellent Young Scholars of Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Innovative research team of high-level local universities in Shanghai
Shanghai Municipal Key Clinical Specialty
Shanghai Clinical Research Center of Plastic and Reconstructive Surgery
Shanghai “Rising Stars of Medical Talent” Youth Development Program
Young Physician Innovation Team Project of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
5 articles.
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