Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo

Author:

Reker Ditte,Kjelgaard-Petersen Cecilie F.,Siebuhr Anne Sofie,Michaelis Martin,Gigout Anne,Karsdal Morten A.,Ladel Christoph,Bay-Jensen Anne C.

Funder

Merck KGaA

The Danish Research Foundation

The Danish Innovation Fund

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference22 articles.

1. Mori Y, Saito T, Chang SH, Kobayashi H, Ladel CH, Guehring H, et al. Identification of fibroblast growth factor-18 as a molecule to protect adult articular cartilage by gene expression profiling. J Biol Chem. 2014;289:10192–200. http://www.ncbi.nlm.nih.gov/pubmed/24577103 . Accessed 6 Mar 2014.

2. Moore EE, Bendele AM, Thompson DL, Littau A, Waggie KS, Reardon B, et al. Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Osteoarthr. Cartil. 2005;13:623–31. http://www.ncbi.nlm.nih.gov/pubmed/15896984 . Accessed 11 July 2013.

3. Power J, Hernandez P, Guehring H, Getgood A, Henson F. Intra-articular injection of rhFGF-18 improves the healing in microfracture treated chondral defects in an ovine model. J Orthop Res. 2014;32:669–76.

4. Dahlberg LE, Aydemir A, Muurahainen N, Gühring H, Fredberg Edebo H, Krarup-Jensen N, et al. A first-in-human, double-blind, randomised, placebo-controlled, dose ascending study of intra-articular rhFGF18 (sprifermin) in patients with advanced knee osteoarthritis. Clin Exp Rheumatol. 2016;34:445–50. http://www.ncbi.nlm.nih.gov/pubmed/27050139 .

5. Lohmander LS, Hellot S, Dreher D, Krantz EFW, Kruger DS, Guermazi A, et al. Intra-articular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol. 2014;66:1820–31. http://www.ncbi.nlm.nih.gov/pubmed/24740822 . Accessed 25 Apr 2014.

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