Abstract
AbstractExtracellular vesicles are heterogeneous populations of naturally occurring secreted small vesicles. EVs function as signaling platforms to facilitate intracellular communication, which indicates the physiological or pathophysiological conditions of cells or tissues. Considering that EVs can be isolated from most body fluids and that molecular constituents could be reprogrammed according to the physiological status of the secreting cells, EVs are regarded as novel diagnostic and prognostic biomarkers for many diseases. The ability to protect encapsulated molecules from degradation in body fluids suggests the potential of EVs as biological medicines or drug delivery systems. This article focuses on the EV-associated biomarkers and therapeutic approaches in autoimmune diseases.
Funder
National Natural Science Foundation of China
Nanjing Medical Science and Technique Development Foundation
Jiangsu Provincial Medical Youth Talent
Science and Technology Support Program of Jiangsu Province
Talent Foundation Project of Nanjing Stomatological Hospital, Medical School of Nanjing University
Nanjing Clinical Research Center for Oral Diseases
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
43 articles.
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