p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis

Author:

Zhang Ting,Li Huihua,Shi Juan,Li Sha,Li Muyuan,Zhang Lei,Zheng Leting,Zheng Dexian,Tang Fulin,Zhang Xuan,Zhang Fengchun,You XinORCID

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Reference52 articles.

1. Tehlirian CV, Bathon JM. Rheumatoid arthritis: A. Clinical and laboratory manifestations. In: Klippel JH, Stone JH, Crofford LJ, While PH, editors. Primer on the rheumatic diseases. New York: Springer; 2008. p. 114–21.

2. Waldenburger JM, Firestein GS. Rheumatoid arthritis: B. Epidemiology, pathology, and pathogenesis. In: Klippel JH, Stone JH, Crofford LJ, While PH, editors. Primer on the rheumatic diseases. 13th ed. New York: Springer; 2008. p. 122–32.

3. Lafyatis R, Remmers EF, Roberts AB, Yocum DE, Sporn MB, Wilder RL. Anchorage-independent growth of synoviocytes from arthritic and normal joints: stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor, and retinoids. J Clin Invest. 1989;83:1267–76.

4. Muller-Ladner U, Kriegsmann J, Franklin BN, Matsumoto S, Geiler T, Gay RE, et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol. 1996;149:1607–15.

5. Aupperle KR, Boyle DL, Hendrix M, Seftor EA, Zvaifler NJ, Barbosa M, et al. Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene. Am J Pathol. 1998;152:1091–8.

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