Author:
Ou Qitian,Cai Gengxin,Zhou Yuan,Zha Wanjie,Huang Linqiang,Zeng Hongke,Jiang Wenqiang,Chen Shenglong,Wen Miaoyun
Abstract
Abstract
Background
Despite the extensive use of arterial catheterization (AC), clinical effectiveness of AC to alter the outcomes among patients with sepsis and septic shock has not been evaluated. The purpose of this study is to examine the association between the use of AC and in-hospital mortality in septic patients.
Methods
Adult patients with sepsis from Medical Information Mart for Intensive Care database were screened to conduct this retrospective observational study. Propensity score matching (PSM) was employed to estimate the relationship between arterial catheterization (AC) and in-hospital mortality. Multivariable logistic regression and inverse probability of treatment weighing (IPTW) were used to validate our findings.
Results
A total of 14,509 septic patients without shock and 4,078 septic shock patients were identified. 3,489 pairs in sepsis patients without shock and 589 pairs in septic shock patients were yielded respectively after PSM. For patients in the sepsis without shock group, AC placement was associated with increased in-hospital mortality (OR, 1.34; 95% CI, 1.17–1.54; p < 0.001). In the septic shock group, there was no significant difference in hospital mortality between AC group and non-AC group. The results of logistic regression and propensity score IPTW model support our findings.
Conclusions
In hemodynamically stable septic patients, AC is independently associated with higher in-hospital mortality, while in patients with septic shock, AC was not associated with improvements in hospital mortality.
Funder
Science and Technology Program of Guangzhou
Guangzhou Science and Technology Project of Guangdong Province of China
GDPH Scientific Research Funds for Leading Medical Talents and Distinguished Young Scholars in Guangdong Province of China
Publisher
Springer Science and Business Media LLC
Subject
Anesthesiology and Pain Medicine