Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Neurology (clinical),Molecular Biology
Link
https://link.springer.com/content/pdf/10.1186/s13024-023-00663-y.pdf
Reference10 articles.
1. Jiang Y, Alam JJ, Gomperts SN, Maruff P, Lemstra AW, Germann UA, et al. Preclinical and randomized clinical evaluation of the p38alpha kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration. Nat Commun. 2022;13(1):5308.
2. Alam J, Maruff P, Doctrow SR, Chu H-M, Conway J, Gomperts SN, et al. Association of plasma phosphorylated tau with the response to neflamapimod treatment in patients with dementia with Lewy bodies. Neurology. 2023. https://doi.org/10.1212/WNL.0000000000207755. Published online ahead of print.
3. Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, et al. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiol Aging. 2016;39:90–8.
4. Jarzebowski P, Tang CS, Paulsen O, Hay YA. Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location. Elife. 2021;10.
5. Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, et al. Reducing endogenous alpha-synuclein mitigates the degeneration of selective neuronal populations in an alzheimer’s disease transgenic mouse model. J Neurosci. 2016;36(30):7971–84.
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