Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

Author:

Gillet Nicolas,Florins Arnaud,Boxus Mathieu,Burteau Catherine,Nigro Annamaria,Vandermeers Fabian,Balon Hervé,Bouzar Amel-Baya,Defoiche Julien,Burny Arsène,Reichert Michal,Kettmann Richard,Willems Luc

Abstract

Abstract In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Virology

Reference358 articles.

1. Leisering A: . Ber Vet -Wes Kgr Sachen. 1871, 16: 15-

2. Burny A, Cleuter Y, Kettmann R, Mammerickx M, Marbaix G, Portetelle D, Van den BA, Willems L, Thomas R: Bovine leukaemia: facts and hypotheses derived from the study of an infectious cancer. Cancer Surv. 1987, 6: 139-159.

3. Olson C, Miller J: . Enzootic bovine leukosis and bovine leukemia virus Martinus Nijhoff Publishing, Boston. 1987, 3-

4. Willems L, Burny A, Dangoisse O, Collete D, Dequiedt F, Gatot JS, Kerkhofs P, Lefebvre L, Merezak C, Portetelle D, Twizere JC, Kettmann R: Bovine leukemia virus as a model for human T-cell leukemia virus. Current Topics in Virology. 1999, 139-167.

5. Meas S, Usui T, Ohashi K, Sugimoto C, Onuma M: Vertical transmission of bovine leukemia virus and bovine immunodeficiency virus in dairy cattle herds. Vet Microbiol. 2002, 84: 275-282. 10.1016/S0378-1135(01)00458-8.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3