siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication-Reference-Cited by-同舟云学术

siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication

Published:2009-08-27 Issue:1 Volume:6 Page:
ISSN:1742-4690
Container-title:Retrovirology
language:en
Short-container-title:Retrovirology

Author:

Kok Kin-Hang,Lei Ting,Jin Dong-Yan

Abstract

Abstract A recent RNAi screen used a genome-wide shRNA library to search for cellular factors required for HIV-1 replication. This work complements three other siRNA-based screening studies and potentially opens the door to the discovery of factors that are important for HIV-1 replication in physiological host cells such as T lymphocytes. shRNA screens can be further improved, and they could promise to unravel new pathways and new facets of virus-cell interactions.

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Virology

Link

https://link.springer.com/content/pdf/10.1186/1742-4690-6-78.pdf

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