Neuropsychopharmacological effects of midazolam on the human brain

Author:

Wang Junkai,Sun Pei,Liang Peipeng

Abstract

Abstract As a commonly used anesthetic agent, midazolam has the properties of water-soluble, rapid onset, and short duration of action. With the rapid development in the field of neuroimaging, numerous studies have investigated how midazolam acts on the human brain to induce the alteration of consciousness. However, the neural bases of midazolam-induced sedation or anesthesia remain beginning to be understood in detail. In this review, we summarize findings from neuroimaging studies that have used midazolam to study altered consciousness at different levels and content. We also compare the results to those of neuroimaging studies using diverse anesthetic agents and describe the common neural correlates of anesthetic-induced alteration of consciousness.

Funder

Beijing Nova Program

Beijing Municipal Science and Technology Project of Brain cognition and brain medicine

Capacity Building for Sci-Tech Innovation - Fundamental Scientific Research Funds

Publisher

Springer Science and Business Media LLC

Subject

Cognitive Neuroscience,Computer Science Applications,Neurology

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