Author:
Spinetti Gaia,Mutoli Martina,Greco Simona,Riccio Federica,Ben-Aicha Soumaya,Kenneweg Franziska,Jusic Amela,de Gonzalo-Calvo David,Nossent Anne Yaël,Novella Susana,Kararigas Georgios,Thum Thomas,Emanueli Costanza,Devaux Yvan,Martelli Fabio
Abstract
AbstractDiabetes mellitus, a group of metabolic disorders characterized by high levels of blood glucose caused by insulin defect or impairment, is a major risk factor for cardiovascular diseases and related mortality. Patients with diabetes experience a state of chronic or intermittent hyperglycemia resulting in damage to the vasculature, leading to micro- and macro-vascular diseases. These conditions are associated with low-grade chronic inflammation and accelerated atherosclerosis. Several classes of leukocytes have been implicated in diabetic cardiovascular impairment. Although the molecular pathways through which diabetes elicits an inflammatory response have attracted significant attention, how they contribute to altering cardiovascular homeostasis is still incompletely understood. In this respect, non-coding RNAs (ncRNAs) are a still largely under-investigated class of transcripts that may play a fundamental role. This review article gathers the current knowledge on the function of ncRNAs in the crosstalk between immune and cardiovascular cells in the context of diabetic complications, highlighting the influence of biological sex in such mechanisms and exploring the potential role of ncRNAs as biomarkers and targets for treatments. The discussion closes by offering an overview of the ncRNAs involved in the increased cardiovascular risk suffered by patients with diabetes facing Sars-CoV-2 infection.Graphical Abstract
Funder
Ministero della Salute
British Heart Foundation
European Union’s Horizon 2020
Instituto de Salud Carlos III
Netherlands Organisation for Scientific Research
Spanish Ministry of Science and Innovation
Icelandic Research Fund
Icelandic Cancer Society Research Fund
University of Iceland Research Fund
Deutsche Forschungsgemeinschaft
ERC Grant REVERSE
EU grant Horizon 2020 Cardioregnix
British Heart Foundation Chair
National Research Fund
Ministry of Higher Education and Research
Heart Foundation-Daniel Wagner of Luxembourg
EU Horizon 2020
cardioRNA COST action
Fondazione Telethon
AFM-Telethon
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine,Endocrinology, Diabetes and Metabolism
Cited by
1 articles.
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