Efficient pathway for men fertility preservation in testicular cancer or lymphoma: a cross-sectional study of national 2018 data
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Published:2023-12-12
Issue:1
Volume:33
Page:
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ISSN:2051-4190
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Container-title:Basic and Clinical Andrology
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language:en
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Short-container-title:Basic Clin. Androl.
Author:
Prades Ségolène, Jos Sarah-Lyne, Saïas-Magnan Jacqueline, Bujan Louis, Eustache Florence, Blagosklonov Oxana, Lechevallier Eric, Brugnon Florence, Loup-Cabaniols Vanessa, Bosquet Dorian, Prades Marie, Ducrocq Bérengère, Chalas Céline, Giscard-d’Estaing Sandrine, Mayeur Anne, Koscinsky Isabelle, Schmitt Françoise, Papaxanthos-Roche Aline, Teletin Marius, Thibault Emmanuelle, Beauvillard Damien, Mirallie Sophie, Delepine Béatrice, Benhaim Annie, May-Panloup Pascale, Veau Ségolène, Frapsauce Cynthia, Fauque Patricia, Costello Régis, Rives Nathalie, Metzler-Guillemain Catherine, Perrin JeanneORCID,
Abstract
Abstract
Background
In 15–49 years-old men, the main cancers are testicular cancer (TC) and lymphomas (L): freezing of ejaculated sperm is primarily used for male fertility preservation (FP) before cancer treatment.
Our objective was to analyze the French FP rate in 15–49 years-old men diagnosed with TC or L in 2018.
We designed a national descriptive cross-sectional study of sperm banking rate in men with a diagnosis of TC, Hodgkin L (HL) or non-Hodgkin L (NHL).
From the French National Cancer Institute (INCa) 2018 data, we extracted the estimated incidence of TC and L in metropolitan France. From the 2018 activity report of CECOS network (Centers for Study and Banking of Eggs and Sperm), we extracted the number of men with TC or L who banked ejaculated sperm. We estimated the proportion of 15–49 years-old men diagnosed with TC or L who banked sperm.
Results
Among 15–49 years-old men, INCa estimated 38,048 new cancer diagnoses in metropolitan France in 2018: 2,630 TC and 3,913 L (943 HL and 2,970 NHL). The CECOS network provided data from 26/27 metropolitan centers (96% response rate): 1,079 sperm banking for men with TC, 375 for HL and 211 for NHL.
We estimated that the 2018 sperm banking rate in France was 41% for TC, 40% for HL, and 7% for NHL.
Conclusions
To our knowledge, our paper is the first cross-sectional study with multicenter and national data analyzing FP rate in cancer men: it suggests an efficient pathway for men to FP before cancer treatment, compared to previously published studies. Although sperm banking rate in 15–49 years-old men could definitely be improved, further studies should evaluate the information given to patients before gonadotoxic treatments, the factors associated with the absence of sperm banking and whether this lack of referral induces a loss of chance for these men.
Publisher
Springer Science and Business Media LLC
Subject
Urology,Reproductive Medicine
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