Author:
Jia Wanyu,Dou Wenjie,Wang Qin,Zeng Huiqin,Shi Peipei,Liu Jing,Liu Zhen,Zhang Jin,Zhang Jian-Jiang
Abstract
Abstract
Background
IgA nephropathy (IgAN) is a common primary renal disease in childhood.
Methods
Twenty blood samples and renal tissue from patients with IgAN, 20 blood samples from healthy children and 10 normal renal tissue were collected. Serum Gd-IgA1 and renal Gd-IgA1, CD31, α-SMA and vimentin were measured.
Results
The serum Gd-IgA1 concentration in the IgAN group was significantly higher. Gd-IgA1 was not expressed in normal kidneys, which was positive in the IgAN group. Gd-IgA1 levels in serum and renal tissue were not related. The expression of CD31 decreased significantly in IgAN group, while the expression of α-SMA and vimentin increased significantly. There was no significant correlation between the renal concentration of Gd-IgA1 and CD31, α-SMA and vimentin.
Conclusion
The increased Gd-IgA1 in the serum and kidney may promote the pathogenesis of IgAN. The serum Gd-IgA1 cannot predict the extent of its deposition in the kidney. Endothelial mesenchymal transition (EndMT) may be involved in the pathogenesis of renal fibrosis in IgAN.
Funder
Key Scientific Research Project of Colleges and Universities in Henan Province
Henan Provincial Science and Technology Research Project
Publisher
Springer Science and Business Media LLC
Reference26 articles.
1. Kidney Disease. Improving global outcomes glomerular Diseases Work G. KDIGO 2021 Clinical Practice Guideline for the management of glomerular Diseases. Kidney Int. 2021;100(4S):1–S276.
2. Hou JH, Zhu HX, Zhou ML, Le WB, Zeng CH, Liang SS, et al. Changes in the spectrum of kidney Diseases: an analysis of 40,759 biopsy-proven cases from 2003 to 2014 in China. Kidney Dis (Basel). 2018;4(1):10–9.
3. Ohyama Y, Renfrow MB, Novak J, Takahashi K. Aberrantly Glycosylated IgA1 in IgA Nephropathy: What We Know and What We Don’t Know. J Clin Med. 2021;10(16).
4. Suzuki H, Fan R, Zhang Z, Brown R, Hall S, Julian BA, et al. Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity. J Clin Invest. 2009;119(6):1668–77.
5. Suzuki H, Allegri L, Suzuki Y, Hall S, Moldoveanu Z, Wyatt RJ, et al. Galactose-deficient IgA1 as a candidate urinary polypeptide marker of IgA Nephropathy? Dis Markers. 2016;2016:7806438.