Author:
Zhang Wen,Yang Shixing,Shen Quan,Liu Junfeng,Shan Tongling,Huang Fen,Ning Huibo,Kang Yanjun,Yang Zhibiao,Cui Li,Zhu Jianguo,Hua Xiuguo
Abstract
Abstract
In the present study, a genotype 4 HEV strain was identified in the fecal specimen from a seven months old infant with no symptom of hepatitis in Shanghai Children's hospital. The full capsid protein gene (ORF2) sequence of this strain was determined by RT-PCR method. Sequence analysis based on the full ORF2 sequence indicated that this HEV strain shared the highest sequence identity (97.6%) with another human HEV strain isolated from a Japanese patient who was infected by genotype 4 HEV during traveling in Shanghai. Phylogenetic analysis showed that this genotype 4 HEV was phylogenetically far from the genotype 4 HEV strain that was commonly prevalent in Shanghai swine group, suggesting that this strain may not come from swine group and not involved in zoonotic transmission in this area.
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology
Reference13 articles.
1. Reyes GR, Purdy MA, Kim JP, Luk KC, Young LM, Fry KE, Bradley DW: Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis. Science 1990, 247: 1335-1339. 10.1126/science.2107574
2. Caron M, Enouf V, Than SC, Dellamonica L, Buisson Y, Nicand E: Identification of genotype 1 hepatitis E virus in samples from swine in Cambodia. J Clin Microbiol 2006, 44: 3440-3442. 10.1128/JCM.00939-06
3. Huang R, Nakazono N, Ishii K, Kawamata O, Kawaguchi R, Tsukada Y: Existing variations on the gene structure of hepatitis E virus strains from some regions of China. J Med Virol 1995, 47: 303-308. 10.1002/jmv.1890470403
4. Panda SK, Thakral D, Rehman S: Hepatitis E virus. Rev Med Virol 2007, 17: 151-180. 10.1002/rmv.522
5. Zhuang H, Cao XY, Liu CB, Wang GM: Enterically transmitted non-A, non-B hepatitis in China. In Viral hepatitis C, D, and E. Edited by: Shikata T, Purcell RH, Uchida T. Amsterdam-New York-Oxford: Excerpta. Medica; 1991:277-285.
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