IGFBP2 drives epithelial-mesenchymal transition in hepatocellular carcinoma via activating the Wnt/β-catenin pathway

Author:

Chen Xiu,Zhang Yu,Zhang Pingping,Wei Mengzhu,Tian Tian,Guan Yanling,Han Chenchen,Wei Wei,Ma Yang

Abstract

AbstractMetastasis has emerged as a major impediment to achieve successful therapeutic outcomes in hepatocellular carcinoma (HCC). Nonetheless, the intricate molecular mechanisms governing the progression of HCC remain elusive. Herein, we present evidence highlighting the influence exerted by insulin-like growth factor-binding protein 2 (IGFBP2) as a potent oncogene driving the malignant phenotype. Our investigation reveals a marked elevation of IGFBP2 expression in primary tumors, concomitant with the presence of mesenchymal biomarkers in HCC. Through in vitro and in vivo experimentation, we demonstrate that the overexpression of IGFBP2 expedites the progression of epithelial-mesenchymal transition (EMT) and facilitates the metastatic potential of HCC cells, chiefly mediated by the Wnt/β-catenin signaling pathway. Notably, knockdown of IGFBP2 significantly decreased the expression of total and nuclear β-catenin, N-cadherin and vimentin in the treatment of the specific activator of Wnt/β-catenin CHIR-99021. Collectively, our findings identify IGFBP2 as a pivotal regulator within the HCC EMT axis, whereby its overexpression confers the distinctly aggressive clinical features characteristic of the disease.

Funder

National Natural Science Foundation of China

the Natural Science Foundation of Anhui Province

the Open Project Program of MOE Key Laboratory of Population Health Across Life Cycle

the Open Fund of Key Laboratory of Anti Inflammatory and Immune Medicine, Ministry of Education

the Open Fund of Key Laboratory of Anti Inflammatory and Immune Medicine, Ministry of Education, China

the Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Infectious Diseases,Oncology,Epidemiology

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