Author:
Huang Li-Juan,Wan Qi,Li Tian,Lv Xing-Yu,Geng Li-Hong,He Qi-Qi,Zhong Zhao-Hui,Li Yuan,Tang Xiao-Jun
Abstract
Abstract
Background
The serum progesterone on human chorionic gonadotropin trigger day / metaphase II oocyte (P/MII) ratio might be a more predictable indicator of pregnancy and neonatal outcomes as compare to P/estradiol (E2) or P alone. Hence, we conducted a larger population study to compare the pregnancy and neonatal outcomes in the low and high P/MII ratio.
Methods
A retrospective, single-center, larger population cohort study between January 2015 and August 2021. Calculate the threshold effect of P/MII ratio on clinical pregnancy rate according to the construct smooth curve fitting. Divide data into two groups by threshold for comparison.
Results
3566 fresh ICSI-ET cycles were included, in which 929 singleton delivery and 676 twin deliveries. Compare to P/MII ≤ 0.367 group, it indicated that the P/MII > 0.367 group had a lower clinical pregnancy rate and live birth rate, furthermore, a significantly higher rate of LBW and SGA were observed in the singleton and twin deliveries. No deleterious impact of high P/MII ratio on embryo quality and undesirable pregnancy outcomes was shown.
Conclusions
When P/MII is higher than 0.367, may have adverse impacts on pregnancy and neonatal outcomes for ICSI cycle.
Funder
Department of Science and Technology of Sichuan Province
Department of Science and Technology of Sichuan province
Publisher
Springer Science and Business Media LLC
Subject
Obstetrics and Gynecology