Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report-Reference-Cited by-全球学者库

Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report

Published:2020-07-29 Issue:1 Volume:15 Page:
ISSN:1749-8090
Container-title:Journal of Cardiothoracic Surgery
language:en
Short-container-title:J Cardiothorac Surg

Author:

Yang Yong,Xie Xiaofeng,Jiang Gening,Liu Hongcheng^ORCID

Abstract

Abstract Background Routine clinical and pathological examinations usually cannot fully conclusively determine the relationship between different lesions of lung cancer. Detailed genetic analysis of tumor samples may supply important additional information and identify second primary lung cancers. Case presentation In the present study, we report a case of synchronous multiple primary lung cancer (MPLC) composed of two distinct pathological subtypes with epidermal growth factor receptor (EGFR) gene mutations L858R of the acinar adenocarcinoma subtype and EML4–ALK rearrangement of the squamous cell carcinoma. Conclusion The present report highlights the clinical importance of molecular cancer biomarkers detection to guide management decisions in MPLC cases.

Funder

Young Scientists Fund

Tongji University

Shanghai Association for Science and Technology

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine,General Medicine,Surgery,Pulmonary and Respiratory Medicine

Link

https://link.springer.com/content/pdf/10.1186/s13019-020-01178-z.pdf

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