Author:
Sharbatoghli Mina,Vafaei Somayeh,Aboulkheyr Es Hamidreza,Asadi-Lari Mohsen,Totonchi Mehdi,Madjd Zahra
Abstract
Abstract
Ovarian cancer is the eighth most commonly occurring cancer in women. Clinically, the limitation of conventional screening and monitoring approaches inhibits high throughput analysis of the tumor molecular markers toward prediction of treatment response. Recently, analysis of liquid biopsies including circulating tumor DNA (ctDNA) open new way toward cancer diagnosis and treatment in a personalized manner in various types of solid tumors. In the case of ovarian carcinoma, growing pre-clinical and clinical studies underscored promising application of ctDNA in diagnosis, prognosis, and prediction of treatment response. In this review, we accumulate and highlight recent molecular findings of ctDNA analysis and its associations with treatment response and patient outcome. Additionally, we discussed the potential application of ctDNA in the personalized treatment of ovarian carcinoma.
Graphical abstract
ctDNA-monitoring usage during the ovarian cancer treatments procedures.
Publisher
Springer Science and Business Media LLC
Subject
Obstetrics and Gynaecology,Oncology
Cited by
21 articles.
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