Author:
Xu Jisheng,Zhu Zhicheng,Jin Yu,Wei Changling,Wang Yi,Li Xue
Abstract
AbstractMethamphetamine (MA) abuse is recognized as a brain disorder, and physical activity has clear benefits for MA use disorders. The specific mechanisms by which physical activity alleviates MA use disorders are currently not fully understood. Based on this, the present study used untargeted metabolomics using liquid chromatography-mass spectrometry (LC-MS) to analyze the metabolic changes induced by MA in the brains of mice by exercise intervention. It was found that after 2 weeks of treadmill training, aerobic exercise modulated MA-induced brain metabolic disorders, in which 129 metabolites existed that were significantly differentiated in response to MA induction, and 32 metabolites were significantly affected by exercise. These differential metabolites were mainly enriched in glycerophospholipid metabolism, steroid hormone biosynthesis and degradation, and renin-angiotensin system pathways. To our knowledge, this study is the first to use LC-MS to investigate the effects of aerobic exercise on MA-induced brain metabolic profiling. The findings of this study provide new insights into exercise therapy using MA.
Funder
the Sichuan Drug Addiction Treatment Administration
the Humanities and Social Sciences Project of the Ministry of Education
the "14th Five Year Plan" Scientific Research and Innovation Team of Chengdu Sport University
the Sichuan Key Laboratory of Sports Medicine
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health
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