Abstract
Abstract
Objective
We aimed to investigate the effect of differentially methylated genes and chronic childhood stress on the development of depressive symptoms in Chinese adolescents, as well as to test whether methylation at baseline can be used as a predictor of remission at follow-up after six weeks of treatment.
Methods
After recruiting 87 MDD patients and 53 healthy controls, we compared demographic and baseline clinical characteristics. The Childhood Chronic Stress Questionnaire was used to assess stress caused by early-life events. MDD patients underwent six weeks of treatment, and response to treatment was assessed using the Beck Depression Inventory-II. In addition, four MDD patients and five controls were randomly chosen for genome-wide methylation analysis.
Results
The gene RPS6KA5 showed significant methylation differences between the two groups. Severity of chronic childhood stress was significantly associated with increased risk of depression in adolescents, but not with treatment response. Baseline RPS6KA5 methylation can predict remission after six weeks of treatment. We did not observe any interaction between RPS6KA5 methylation and chronic childhood stress.
Conclusions
Our results suggest that RPS6KA5 methylation can be used as a predictor of response to treatment in adolescent MDD patients. Here we offer new evidence for the role of epigenetics in early response to treatment of depression.
Trial registration
ChiCTR, ChiCTR2000033402, 31/05/2020, http://www.chictr.org.cn/index.aspx
Funder
National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
Department of Science and Technology of Sichuan Province
Health Commission of Sichuan Province
Chengdu Science and Technology Bureau
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health
Cited by
1 articles.
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