Author:
Yang Xu,Yang Haidong,Li Na,Li Chunyu,Liang Weiye,Zhang Xiaobin
Abstract
Abstract
Background
Accumulating evidence shows that homocysteine (Hcy) is implicated in the pathophysiology of schizophrenia, and plays an important role in clinical characteristics. This study evaluated the relationships between Hcy levels and clinical features in first-episode, Chinese Han, drug-naïve (FEDN) patients with schizophrenia.
Methods
FEDN individuals (119 with schizophrenia and 81 healthy controls matched for age, sex, education, and body mass index (BMI)) were enrolled. The serum Hcy levels were determined by enzyme cycle assay experiments. Severities of clinical symptoms were rated on the Positive and Negative Syndrome Scale (PANSS).
Results
FEDN individuals with schizophrenia had higher Hcy levels compared with healthy controls (F = 46.865, P < 0.001). Correlation analysis and multiple stepwise regression analyses showed that serum Hcy levels in FEDN schizophrenia individuals were positively correlated with PANSS general psychopathology subscale (r = 0.294, P = 0.001) and PANSS total score (r = 0.273, P = 0.003). No significant association was found between Hcy and age, BMI, PANSS positive subscale, and the PANSS negative subscale (all, P > 0.05). Male individuals had significantly higher serum Hcy levels than female individuals (F = 7.717, P = 0.006) after controlling for confounding factors (F = 0.759, P = 0.011).
Conclusions
Serum Hcy levels were increased in FEDN individuals with schizophrenia, and Hcy levels may be involved in pathophysiological mechanisms. Sex differences in Hcy levels were observed, with higher levels in male FEDN individuals compared to females.
Funder
The Capital Health Research and Development of Special
General Program of Lianyungang Health Committee
Suzhou Clinical Medical Center for Mood Disorders
Suzhou Clinical Key disciplines for Geriatric Psychiatry
Suzhou Key Technology Research
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health
Reference57 articles.
1. McCutcheon RA, Reis Marques T, Howes OD. Schizophrenia-An Overview. JAMA Psychiat. 2020;77(2):201–10.
2. Carra G, Crocamo C, Angermeyer M, Brugha T, Toumi M, Bebbington P. Positive and negative symptoms in schizophrenia: A longitudinal analysis using latent variable structural equation modelling. Schizophr Res. 2019;204:58–64.
3. Mihaljević-Peleš A, BajsJanović M, Šagud M, Živković M, Janović Š, Jevtović S. Cognitive deficit in schizophrenia: an overview. Psychiatr Danub. 2019;31(Suppl 2):139–42.
4. Zhong Q, Tan Y, Chen W, Huang H, Huang J, Li S, Teng Z, Shen M, Wu C, Wang L, et al. Disease burden of schizophrenia patients visiting a Chinese regional mental health centre. J Comp Eff Res. 2020;9(7):469–81.
5. Chen R, Liou TH, Miao NF, Chang KH, Yen CF, Liao HF, Chi WC, Chou KR. Using World Health Organization Disability Assessment Schedule 2.0 in people with schizophrenia: a 4-year follow-up. Eur Arch Psychiatry Clin Neurosci. 2020;270(3):301–10.
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