Author:
Kajikawa Keita,Imaizumi Kent,Shinozaki Munehisa,Shibata Shinsuke,Shindo Tomoko,Kitagawa Takahiro,Shibata Reo,Kamata Yasuhiro,Kojima Kota,Nagoshi Narihito,Matsumoto Morio,Nakamura Masaya,Okano Hideyuki
Abstract
AbstractThe transplantation of neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (iPSCs) has beneficial effects on spinal cord injury (SCI). However, while there are many subtypes of NPCs with different regional identities, the subtype of iPSC-derived NPCs that is most appropriate for cell therapy for SCI has not been identified. Here, we generated forebrain- and spinal cord-type NPCs from human iPSCs and grafted them onto the injured spinal cord in mice. These two types of NPCs retained their regional identities after transplantation and exhibited different graft-host interconnection properties. NPCs with spinal cord regional identity but not those with forebrain identity resulted in functional improvement in SCI mice, especially in those with mild-to-moderate lesions. This study highlights the importance of the regional identity of human iPSC-derived NPCs used in cell therapy for SCI.
Funder
Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science
General Insurance Association of Japan
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Molecular Biology
Cited by
47 articles.
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