Author:
Chen Song-Feng,Pan Meng-Xian,Tang Jun-Chun,Cheng Jing,Zhao Dan,Zhang Ya,Liao Hua-Bao,Liu Rui,Zhuang Yang,Zhang Zhi-Feng,Chen Juan,Lei Rui-Xue,Li Shi-Fang,Li Huan-Ting,Wang Ze-Fen,Wan Qi
Abstract
AbstractNeuroinflammation is a secondary response following ischemia stroke. Arginine is a non-essential amino acid that has been shown to inhibit acute inflammatory reaction. In this study we show that arginine treatment decreases neuronal death after rat cerebral ischemia/reperfusion (I/R) injury and improves functional recovery of stroke animals. We also show that arginine suppresses inflammatory response in the ischemic brain tissue and in the cultured microglia after OGD insult. We further provide evidence that the levels of HIF-1α and LDHA are increased after rat I/R injury and that arginine treatment prevents the elevation of HIF-1α and LDHA after I/R injury. Arginine inhibits inflammatory response through suppression of HIF-1α and LDHA in the rat ischemic brain tissue and in the cultured microglia following OGD insult, and protects against ischemic neuron death after rat I/R injury by attenuating HIF-1α/LDHA-mediated inflammatory response. Together, these results indicate a possibility that arginine-induced neuroprotective effect may be through the suppression of HIF-1α/LDHA-mediated inflammatory response in microglia after cerebral ischemia injury.
Funder
National Natural Science Foundation of China
Key Technology Research and Development Program of Shandong
Key Technologies Research and Development Program
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Molecular Biology
Cited by
40 articles.
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