The effect of mofettes and natural carbonated mineral water on accelerating bone healing in a femoral defect model in rats-Reference-Cited by-同舟云学术

The effect of mofettes and natural carbonated mineral water on accelerating bone healing in a femoral defect model in rats

Published:2024-03-31 Issue:Vol.15, no.1 Volume:15 Page:650-650
ISSN:2734-8458
Container-title:Balneo and PRM Research Journal
language:en
Short-container-title:

Author:

Dogaru Gabriela¹,Oltean-Dan Daniel²,Rus Vasile³,Gherman Luciana Mădălina⁴,Ciubean Alina Deniza¹,Dindelegan Maximilian George⁵,Pop Bianca⁶,Pașca Gabriel⁶,Ciumărnean Lorena⁷

Affiliation:

1. 1 "Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania, Department of Medical Rehabilitation

2. 3 Department of Orthopedics and Traumatology, Iuliu Hatieganu University of Medicine and Pharma

3. 4 University of Agricultural Sciences and Veterinary Medicine, Department of Cell Biology, Histology and Embriology

4. 5 Experimental Centre, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, Romania

5. 6 Department of Orthorinolaringology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania

6. 7 Doctoral School of Biomedical Sciences, University of Oradea

7. 8 Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca,Romania, 5th Department of Internal Medicine

Abstract

Abstract: (1) Background: The aim of the study was to investigate the effecs of mofettes and car-bonated mineral water baths on bone healing using a rat femoral defect model; (2) Methods: A 2mm diameter unicortical defect in the left femoral diaphysis in 40 Wistar Rats was surgically created. Furthermore, the subjects were divided into 4 treatment-groups: control, mofette therapy, mofette therapy and carbonated mineral water bath, and carbonated mineral water bath. At the end of the 2-week treatment and at 4 and 6 weeks, the animals were evaluated through Micro-CT analysis of the bone defect and histological analysis of bone tissue and skin; (3) Results: The pro-cesses of bone consolidation and repair are not completed at 6 weeks in all groups. However, comparing the proliferated bone tissue in the created orifice and the degree of thickening of the femoral wall, it can be affirmed that at 6 weeks, the best results are present in Group 4, treated with carbonated mineral water baths, followed by the combination of mofettes and carbonated water. (4) The use of these treatments could open a new possibility for shortening the healing time in patients with bone defects, as it is non-invasive and accessible.

Publisher

Romanian Association of Balneology

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