Cutaneous Melanoma, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology

Author:

Coit Daniel G.1,Thompson John A.2,Albertini Mark R.3,Barker Christopher1,Carson William E.4,Contreras Carlo5,Daniels Gregory A.6,DiMaio Dominick7,Fields Ryan C.8,Fleming Martin D.9,Freeman Morganna10,Galan Anjela11,Gastman Brian12,Guild Valerie13,Johnson Douglas14,Joseph Richard W.15,Lange Julie R.16,Nath Sameer17,Olszanski Anthony J.18,Ott Patrick19,Gupta Aparna Priyanath20,Ross Merrick I.21,Salama April K.22,Skitzki Joseph23,Sosman Jeffrey20,Swetter Susan M.24,Tanabe Kenneth K.25,Wuthrick Evan26,McMillian Nicole R.27,Engh Anita M.27

Affiliation:

1. 1Memorial Sloan Kettering Cancer Center;

2. 2Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

3. 3University of Wisconsin Carbone Cancer Center;

4. 4The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

5. 5University of Alabama at Birmingham Comprehensive Cancer Center;

6. 6UC San Diego Moores Cancer Center;

7. 7Fred & Pamela Buffett Cancer Center;

8. 8Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

9. 9St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center;

10. 10City of Hope National Medical Center;

11. 11Yale Cancer Center/Smilow Cancer Hospital;

12. 12Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

13. 13Aim at Melanoma;

14. 14Vanderbilt-Ingram Cancer Center;

15. 15Mayo Clinic Cancer Center;

16. 16The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

17. 17University of Colorado Cancer Center;

18. 18Fox Chase Cancer Center;

19. 19Dana-Farber/Brigham and Women's Cancer Center;

20. 20Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

21. 21The University of Texas MD Anderson Cancer Center;

22. 22Duke Cancer Institute;

23. 23Roswell Park Comprehensive Cancer Center;

24. 24Stanford Cancer Institute;

25. 25Massachusetts General Hospital Cancer Center;

26. 26Moffitt Cancer Center; and

27. 27National Comprehensive Cancer Network

Abstract

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Cutaneous melanoma have been significantly revised over the past few years in response to emerging data on immune checkpoint inhibitor therapies and BRAF-targeted therapy. This article summarizes the data and rationale supporting extensive changes to the recommendations for systemic therapy as adjuvant treatment of resected disease and as treatment of unresectable or distant metastatic disease.

Publisher

Harborside Press, LLC

Subject

Oncology

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