Acute Lymphoblastic Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

Author:

Brown Patrick A.1,Shah Bijal2,Advani Anjali3,Aoun Patricia4,Boyer Michael W.5,Burke Patrick W.6,DeAngelo Daniel J.7,Dinner Shira8,Fathi Amir T.9,Gauthier Jordan10,Jain Nitin11,Kirby Suzanne12,Liedtke Michaela13,Litzow Mark14,Logan Aaron15,Luger Selina16,Maness Lori J.17,Massaro Stephanie18,Mattison Ryan J.19,May William20,Oluwole Olalekan21,Park Jae22,Przespolewski Amanda23,Rangaraju Sravanti24,Rubnitz Jeffrey E.25,Uy Geoffrey L.26,Vusirikala Madhuri27,Wieduwilt Matthew28,Lynn Beth29,Berardi Ryan A.29,Freedman-Cass Deborah A.29,Campbell Mallory29

Affiliation:

1. 1The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

2. 2Moffitt Cancer Center;

3. 3Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

4. 4City of Hope National Medical Center;

5. 5Huntsman Cancer Institute at the University of Utah;

6. 6University of Michigan Rogel Cancer Center;

7. 7Dana-Farber/Brigham and Women’s Cancer Center;

8. 8Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

9. 9Massachusetts General Hospital Cancer Center;

10. 10Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

11. 11The University of Texas MD Anderson Cancer Center;

12. 12Duke Cancer Institute;

13. 13Stanford Cancer Institute;

14. 14Mayo Clinic Cancer Center;

15. 15UCSF Helen Diller Family Comprehensive Cancer Center;

16. 16Abramson Cancer Center at the University of Pennsylvania;

17. 17Fred & Pamela Buffett Cancer Center;

18. 18Yale Cancer Center/Smilow Cancer Hospital;

19. 19University of Wisconsin Carbone Cancer Center;

20. 20UCLA Jonsson Comprehensive Cancer Center;

21. 21Vanderbilt-Ingram Cancer Center;

22. 22Memorial Sloan Kettering Cancer Center;

23. 23Roswell Park Comprehensive Cancer Center;

24. 24O'Neal Comprehensive Cancer Center at UAB;

25. 25St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center;

26. 26Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

27. 27UT Southwestern Simmons Comprehensive Cancer Center;

28. 28UC San Diego Moores Cancer Center; and

29. 29National Comprehensive Cancer Network.

Abstract

The NCCN Guidelines for Acute Lymphoblastic Leukemia (ALL) focus on the classification of ALL subtypes based on immunophenotype and cytogenetic/molecular markers; risk assessment and stratification for risk-adapted therapy; treatment strategies for Philadelphia chromosome (Ph)-positive and Ph-negative ALL for both adolescent and young adult and adult patients; and supportive care considerations. Given the complexity of ALL treatment regimens and the required supportive care measures, the NCCN ALL Panel recommends that patients be treated at a specialized cancer center with expertise in the management of ALL This portion of the Guidelines focuses on the management of Ph-positive and Ph-negative ALL in adolescents and young adults, and management in relapsed settings.

Publisher

Harborside Press, LLC

Subject

Oncology

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