NCCN Guidelines® Insights: Myelodysplastic Syndromes, Version 3.2022

Author:

Greenberg Peter L.1,Stone Richard M.2,Al-Kali Aref3,Bennett John M.4,Borate Uma5,Brunner Andrew M.6,Chai-Ho Wanxing7,Curtin Peter8,de Castro Carlos M.9,Deeg H. Joachim10,DeZern Amy E.11,Dinner Shira12,Foucar Charles13,Gaensler Karin14,Garcia-Manero Guillermo15,Griffiths Elizabeth A.16,Head David17,Jonas Brian A.18,Keel Sioban10,Madanat Yazan19,Maness Lori J.20,Mangan James21,McCurdy Shannon22,McMahon Christine23,Patel Bhumika24,Reddy Vishnu V.25,Sallman David A.26,Shallis Rory27,Shami Paul J.28,Thota Swapna29,Varshavsky-Yanovsky Asya Nina30,Westervelt Peter31,Hollinger Elizabeth32,Shead Dorothy A.32,Hochstetler Cindy32

Affiliation:

1. 1Stanford Cancer Institute;

2. 2Dana-Farber/Brigham and Women’s Cancer Center;

3. 3Mayo Clinic Cancer Center;

4. 4University of Rochester;

5. 5The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute;

6. 6Massachusetts General Hospital Cancer Center;

7. 7UCLA Jonsson Comprehensive Cancer Center;

8. 8City of Hope National Medical Center;

9. 9Duke Cancer Institute;

10. 10Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

11. 11The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

12. 12Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

13. 13University of Michigan Rogel Cancer Center;

14. 14UCSF Helen Diller Family Comprehensive Cancer Center;

15. 15The University of Texas MD Anderson Cancer Center;

16. 16Roswell Park Comprehensive Cancer Center;

17. 17Vanderbilt-Ingram Cancer Center;

18. 18UC Davis Comprehensive Cancer Center;

19. 19UT Southwestern Simmons Comprehensive Cancer Center;

20. 20Fred & Pamela Buffett Cancer Center;

21. 21UC San Diego Moores Cancer Center;

22. 22Abramson Cancer Center at the University of Pennsylvania;

23. 23University of Colorado Cancer Center;

24. 24Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

25. 25O'Neal Comprehensive Cancer Center at UAB;

26. 26Moffitt Cancer Center;

27. 27Yale Cancer Center/Smilow Cancer Hospital;

28. 28Huntsman Cancer Institute at the University of Utah;

29. 29St. Jude Children's Research Hospital/The University of Tennessee Health Science Center;

30. 30Fox Chase Cancer Center;

31. 31Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; and

32. 32National Comprehensive Cancer Network.

Abstract

The NCCN Guidelines for Myelodysplastic Syndromes (MDS) provide recommendations for the evaluation, diagnosis, and management of patients with MDS based on a review of clinical evidence that has led to important advances in treatment or has yielded new information on biologic factors that may have prognostic significance in MDS. The multidisciplinary panel of MDS experts meets on an annual basis to update the recommendations. These NCCN Guidelines Insights focus on some of the updates for the 2022 version of the NCCN Guidelines, which include treatment recommendations both for lower-risk and higher-risk MDS, emerging therapies, supportive care recommendations, and genetic familial high-risk assessment for hereditary myeloid malignancy predisposition syndromes.

Publisher

Harborside Press, LLC

Subject

Oncology

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