NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021

Author:

Pollyea Daniel A.1,Bixby Dale2,Perl Alexander3,Bhatt Vijaya Raj4,Altman Jessica K.5,Appelbaum Frederick R.6,de Lima Marcos7,Fathi Amir T.8,Foran James M.9,Gojo Ivana10,Hall Aric C.11,Jacoby Meagan12,Lancet Jeffrey13,Mannis Gabriel14,Marcucci Guido15,Martin Michael G.16,Mims Alice17,Neff Jadee18,Nejati Reza19,Olin Rebecca20,Percival Mary-Elizabeth6,Prebet Thomas21,Przespolewski Amanda22,Rao Dinesh23,Ravandi-Kashani Farhad24,Shami Paul J.25,Stone Richard M.26,Strickland Stephen A.27,Sweet Kendra13,Vachhani Pankit28,Wieduwilt Matthew29,Gregory Kristina M.30,Ogba Ndiya30,Tallman Martin S.31

Affiliation:

1. 1University of Colorado Cancer Center;

2. 2University of Michigan Rogel Cancer Center;

3. 3Abramson Cancer Center at the University of Pennsylvania;

4. 4Fred & Pamela Buffett Cancer Center;

5. 5Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

6. 6Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

7. 7Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

8. 8Massachusetts General Hospital Cancer Center;

9. 9Mayo Clinic Cancer Center;

10. 10The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

11. 11University of Wisconsin Carbone Cancer Center;

12. 12Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

13. 13Moffitt Cancer Center;

14. 14Stanford Cancer Institute;

15. 15City of Hope National Medical Center;

16. 16St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center;

17. 17The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

18. 18Duke Cancer Institute;

19. 19Fox Chase Cancer Center;

20. 20UCSF Helen Diller Family Comprehensive Cancer Center;

21. 21Yale Cancer Center/Smilow Cancer Hospital;

22. 22Roswell Park Comprehensive Cancer Center;

23. 23UCLA Jonsson Comprehensive Cancer Center;

24. 24The University of Texas MD Anderson Cancer Center;

25. 25Huntsman Cancer Institute at the University of Utah;

26. 26Dana-Farber/Brigham and Women’s Cancer Center;

27. 27Vanderbilt-Ingram Cancer Center;

28. 28O'Neal Comprehensive Cancer Center at UAB;

29. 29UC San Diego Moores Cancer Center;

30. 30National Comprehensive Cancer Network; and

31. 31Memorial Sloan Kettering Cancer Center.

Abstract

The NCCN Guidelines for Acute Myeloid Leukemia (AML) provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment, or have yielded new information regarding factors with prognostic importance, and are intended to aid physicians with clinical decision-making. These NCCN Guidelines Insights focus on recent select updates to the NCCN Guidelines, including familial genetic alterations in AML, postinduction or postremission treatment strategies in low-risk acute promyelocytic leukemia or favorable-risk AML, principles surrounding the use of venetoclax-based therapies, and considerations for patients who prefer not to receive blood transfusions during treatment.

Publisher

Harborside Press, LLC

Subject

Oncology

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