NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities, Version 1.2020

Author:

Thompson John A.1,Schneider Bryan J.2,Brahmer Julie3,Andrews Stephanie4,Armand Philippe5,Bhatia Shailender1,Budde Lihua E.6,Costa Luciano7,Davies Marianne8,Dunnington David9,Ernstoff Marc S.10,Frigault Matthew11,Kaffenberger Benjamin H.12,Lunning Matthew13,McGettigan Suzanne14,McPherson Jordan15,Mohindra Nisha A.16,Naidoo Jarushka3,Olszanski Anthony J.17,Oluwole Olalekan18,Patel Sandip P.19,Pennell Nathan20,Reddy Sunil21,Ryder Mabel22,Santomasso Bianca23,Shofer Scott24,Sosman Jeffrey A.16,Wang Yinghong25,Weight Ryan M.26,Johnson-Chilla Alyse27,Zuccarino-Catania Griselda27,Engh Anita27

Affiliation:

1. 1Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

2. 2University of Michigan Rogel Cancer Center;

3. 3The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

4. 4Moffitt Cancer Center;

5. 5Dana-Farber/Brigham and Women’s Cancer Center;

6. 6City of Hope National Medical Center;

7. 7O’Neal Comprehensive Cancer Center at UAB;

8. 8Yale Cancer Center/Smilow Cancer Hospital;

9. 9Patient Advocate;

10. 10Roswell Park Comprehensive Cancer Center;

11. 11Massachusetts General Hospital Cancer Center;

12. 12The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

13. 13Fred & Pamela Buffett Cancer Center;

14. 14Abramson Cancer Center at the University of Pennsylvania;

15. 15Huntsman Cancer Institute at the University of Utah;

16. 16Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

17. 17Fox Chase Cancer Center;

18. 18Vanderbilt-Ingram Cancer Center;

19. 19UC San Diego Moores Cancer Center;

20. 20Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

21. 21Stanford Cancer Institute;

22. 22Mayo Clinic Cancer Center;

23. 23Memorial Sloan Kettering Cancer Center;

24. 24Duke Cancer Institute;

25. 25The University of Texas MD Anderson Cancer Center;

26. 26University of Colorado Cancer Center; and

27. 27National Comprehensive Cancer Network.

Abstract

The NCCN Guidelines for Management of Immunotherapy-Related Toxicities provide interdisciplinary guidance on the management of immune-related adverse events (irAEs) resulting from cancer immunotherapy. These NCCN Guidelines Insights describe symptoms that may be caused by an irAE and should trigger further investigation, and summarize the NCCN Management of Immunotherapy-Related Toxicities Panel discussions for the 2020 update to the guidelines regarding immune checkpoint inhibitor–related diarrhea/colitis and cardiovascular irAEs.

Publisher

Harborside Press, LLC

Subject

Oncology

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