Management of Immunotherapy-Related Toxicities, Version 1.2022, NCCN Clinical Practice Guidelines in Oncology

Author:

Thompson John A.1,Schneider Bryan J.2,Brahmer Julie3,Achufusi Amaka4,Armand Philippe5,Berkenstock Meghan K.3,Bhatia Shailender1,Budde Lihua E.6,Chokshi Saurin7,Davies Marianne8,Elshoury Amro9,Gesthalter Yaron10,Hegde Aparna11,Jain Michael12,Kaffenberger Benjamin H.13,Lechner Melissa G.14,Li Tianhong15,Marr Alissa16,McGettigan Suzanne17,McPherson Jordan18,Medina Theresa19,Mohindra Nisha A.20,Olszanski Anthony J.21,Oluwole Olalekan22,Patel Sandip P.23,Patil Pradnya24,Reddy Sunil25,Ryder Mabel26,Santomasso Bianca27,Shofer Scott28,Sosman Jeffrey A.20,Wang Yinghong29,Zaha Vlad G.30,Lyons Megan31,Dwyer Mary31,Hang Lisa31

Affiliation:

1. 1Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

2. 2University of Michigan Rogel Cancer Center;

3. 3The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

4. 4University of Wisconsin Carbone Cancer Center;

5. 5Dana-Farber/Brigham and Women’s Cancer Center;

6. 6City of Hope National Medical Center;

7. 7St. Jude Children's Research Hospital/The University of Tennessee Health Science Center;

8. 8Yale Cancer Center/Smilow Cancer Hospital;

9. 9Roswell Park Comprehensive Cancer Center;

10. 10UCSF Helen Diller Family Comprehensive Cancer Center;

11. 11O'Neal Comprehensive Cancer Center at UAB;

12. 12Moffitt Cancer Center;

13. 13The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

14. 14UCLA Jonsson Comprehensive Cancer Center;

15. 15UC Davis Comprehensive Cancer Center;

16. 16Fred & Pamela Buffett Cancer Center;

17. 17Abramson Cancer Center at the University of Pennsylvania;

18. 18Huntsman Cancer Institute at the University of Utah;

19. 19University of Colorado Cancer Center;

20. 20Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

21. 21Fox Chase Cancer Center;

22. 22Vanderbilt-Ingram Cancer Center;

23. 23UC San Diego Moores Cancer Center;

24. 24Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

25. 25Stanford Cancer Institute;

26. 26Mayo Clinic Cancer Center;

27. 27Memorial Sloan Kettering Cancer Center;

28. 28Duke Cancer Institute;

29. 29The University of Texas MD Anderson Cancer Center;

30. 30UT Southwestern Simmons Comprehensive Cancer Center; and

31. 31National Comprehensive Cancer Network

Abstract

The aim of the NCCN Guidelines for Management of Immunotherapy-Related Toxicities is to provide guidance on the management of immune-related adverse events resulting from cancer immunotherapy. The NCCN Management of Immunotherapy-Related Toxicities Panel is an interdisciplinary group of representatives from NCCN Member Institutions, consisting of medical and hematologic oncologists with expertise across a wide range of disease sites, and experts from the areas of dermatology, gastroenterology, endocrinology, neurooncology, nephrology, cardio-oncology, ophthalmology, pulmonary medicine, and oncology nursing. The content featured in this issue is an excerpt of the recommendations for managing toxicities related to CAR T-cell therapies and a review of existing evidence. For the full version of the NCCN Guidelines, including recommendations for managing toxicities related to immune checkpoint inhibitors, visitNCCN.org.

Publisher

Harborside Press, LLC

Subject

Oncology

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