NCCN Guidelines® Insights: Ovarian Cancer, Version 3.2022

Author:

Armstrong Deborah K.1,Alvarez Ronald D.2,Backes Floor J.3,Bakkum-Gamez Jamie N.4,Barroilhet Lisa5,Behbakht Kian6,Berchuck Andrew7,Chen Lee-may8,Chitiyo Viola C.9,Cristea Mihaela10,DeRosa Maria11,Eisenhauer Eric L.12,Gershenson David M.13,Gray Heidi J.14,Grisham Rachel9,Hakam Ardeshir15,Jain Angela16,Karam Amer17,Konecny Gottfried E.18,Leath III Charles A.19,Leiserowitz Gary20,Liu Joyce21,Martin Lainie22,Matei Daniela23,McHale Michael24,McLean Karen25,Miller David S.26,Percac-Lima Sanja12,Remmenga Steven W.27,Schorge John28,Stewart Daphne10,Thaker Premal H.29,Vargas Roberto30,Hendrickson Andrea Wahner4,Werner Theresa L.31,Zsiros Emese32,Dwyer Mary A.33,Hang Lisa33

Affiliation:

1. 1The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

2. 2Vanderbilt-Ingram Cancer Center;

3. 3The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

4. 4Mayo Clinic Cancer Center;

5. 5University of Wisconsin Carbone Cancer Center;

6. 6University of Colorado Cancer Center;

7. 7Duke Cancer Institute;

8. 8UCSF Helen Diller Family Comprehensive Cancer Center;

9. 9Memorial Sloan Kettering Cancer Center;

10. 10City of Hope National Medical Center;

11. 11Patient advocate;

12. 12Massachusetts General Hospital Cancer Center;

13. 13The University of Texas MD Anderson Cancer Center;

14. 14University of Washington/Seattle Cancer Care Alliance;

15. 15Moffitt Cancer Center;

16. 16Fox Chase Cancer Center;

17. 17Stanford Cancer Institute;

18. 18UCLA Jonsson Comprehensive Cancer Center;

19. 19O'Neal Comprehensive Cancer Center at UAB;

20. 20UC Davis Comprehensive Cancer Center;

21. 21Dana-Farber/Brigham and Women’s Cancer Center;

22. 22Abramson Cancer Center at the University of Pennsylvania;

23. 23Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

24. 24UC San Diego Moores Cancer Center;

25. 25University of Michigan Rogel Cancer Center;

26. 26UT Southwestern Simmons Comprehensive Cancer Center;

27. 27Fred & Pamela Buffett Cancer Center;

28. 28St. Jude Children's Research Hospital/The University of Tennessee Health Science Center;

29. 29Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

30. 30Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

31. 31Huntsman Cancer Institute at the University of Utah;

32. 32Roswell Park Comprehensive Cancer Center; and

33. 33National Comprehensive Cancer Network.

Abstract

Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the United States, with less than half of patients living >5 years following diagnosis. The NCCN Guidelines for Ovarian Cancer provide recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with ovarian, fallopian tube, and primary peritoneal cancers. These NCCN Guidelines Insights summarize the panel discussion behind recent important updates to the guidelines, including revised guidance on alternative chemotherapy regimens for patients with advanced age and/or comorbidities, a new algorithm for recurrent low-grade serous carcinoma based on developing research and novel therapeutic agents, and updated language regarding tumor molecular analysis applications in ovarian cancer.

Publisher

Harborside Press, LLC

Subject

Oncology

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