Author:
Bai Si-Jun,Geng Ye,Gao Yi-Nan,Zhang Cai-Xia,Mi Qian,Zhang Chen,Yang Jia-Ling,He Si-Jie,Yan Zhen-Ying,He Jian-Xia
Abstract
BACKGROUND
Marginal zone lymphoma (MZL) is an indolent subtype of non-Hodgkin lymphoma (NHL), which is rare clinically with severe rashes as the initial symptom.
CASE SUMMARY
This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge. First-line treatment with rituximab combined with zanubrutinib had poor effects. However, after switching to obinutuzumab combined with zanubrutinib, the case was alleviated, and the rashes disappeared.
CONCLUSION
For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody (mAb) combination therapy, switching to a type II anti-CD20 mAb combination regimen may be considered. This approach may provide a new perspective in the treatment of MZL.
Publisher
Baishideng Publishing Group Inc.