Individual approach to metastatic colorectal cancer treatment (clinical cases)

Author:

Kit O. I.1ORCID,Gevorkyan Yu. A.1ORCID,Soldatkina N. V.1ORCID,Vladimirova L. Yu.1ORCID,Popova I. L.1ORCID,Bondarenko O. K.1ORCID,Dashkov A. V.1ORCID,Kolesnikov V. E.1ORCID

Affiliation:

1. Federal State Budgetary Institution “National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation

Abstract

Two patients with metastatic colorectal cancer underwent R0 large bowel resection followed by surgery liver and lungs metastases, retroperitoneal lymph nodes and post-op chemotherapy. The total follow-up period of the first patient was currently 12 years, the recurrence-free period was 5 years. In the second patient, stabilization of the disease was observed for 12 years, and the total follow-up period – 18.5 years. An integrated treatment approach to metastatic CRC with active surgery for removable distant metastases or perioperative use of the most effective drug therapy for potentially resectable metastases can control the disease even with an aggressive course.

Publisher

Russian Association of Coloproctology

Subject

Gastroenterology,Oncology,Surgery

Reference12 articles.

1. Kit O.I., Gevorkyan Yu.A., Soldatkina N.V., et al. Modern prognostic factors in colorectal cancer. Koloproktologia. 2021;20(2):42–49. (in Russ.). doi: 10.33878/2073-7556-2021-20-2-42-49

2. Kit O.I., Gevorkyan Yu.A., Soldatkina N.V., et al. Features of KRAS gene mutations in colorectal cancer in the south of Russia. Tyumen Medical Journal. 2015;17(3):20–22. eLibrary ID: 24850804. (in Russ.).

3. Vodolazhsky D.I., Antonets A.V., Dvadnenko K.V., et al. Connection of KRAS gene mutations with clinical and pathological features of colorectal cancer in patients of the South of Russia. International Journal of Experimental Education. 2014;1-1: 65-68. Available by: https://expeducation.ru/ru/article/view?id=4517 (accessed: 07/14/2023). (in Russ.).

4. Petrelli F, Tomasello G, Borgonovo K, et al. Prognostic Survival Associated With Left-Sided vs Right-Sided Colon Cancer: A Systematic Review and Meta-analysis. JAMA Oncol. 2017;Feb 1;3(2):211–219. doi: 10.1001/jamaoncol.2016.4227

5. Xie MZ, Li JL, Cai ZM, et al. Impact of primary colorectal Cancer location on the KRAS status and its prognostic value. BMC Gastroenterol. 2019;Mar 27;19(1):46. doi: 10.1186/s12876-019-0965-5

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3