Reprogramming Interferon Regulatory Factor Signaling in Cardiometabolic Diseases-Reference-Cited by-同舟云学术

Reprogramming Interferon Regulatory Factor Signaling in Cardiometabolic Diseases

Published:2017-05 Issue:3 Volume:32 Page:210-223
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Zhang Yaxing¹²³,Li Hongliang¹²³

Affiliation:

1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China;

2. Institute of Model Animal, Wuhan University, Wuhan, People's Republic of China; and

3. Medical Research Institute, School of Medicine, Wuhan University, Wuhan, People's Republic of China

Abstract

Interferon regulatory factors (IRFs) are evolutionarily conserved proteins expressed not only in immune cells but also in other tissues and organs outside the immune system. In this review, we discuss mechanisms responsible for IRF-mediated innate immune responses and the function and mechanism of IRFs in cardiometabolic diseases. We focus on the role of IRFs in innate immunity and cardiometabolic homeostasis, and highlight reprogrammed IRF signaling.

Funder

the National Science Fund for Distinguished Young Scholars

the Key Project of the National Natural Science Foundation

National Natural Science Foundation of China (NSFC)

National Science and Technology Support Project

China Postdoctoral Science Foundation

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00038.2016