Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction-Reference-Cited by-同舟云学术

Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction

Published:2023-09-01 Issue:5 Volume:38 Page:217-230
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Daou Daniel¹,Gillette Thomas G.¹,Hill Joseph A.¹²^ORCID

Affiliation:

1. Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, Texas, United States

2. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States

Abstract

Heart failure with preserved ejection fraction (HFpEF) is now the most common form of heart failure and a significant public health concern for which limited effective therapies exist. Inflammation triggered by comorbidity burden is a critical element of HFpEF pathophysiology. Here, we discuss evidence for comorbidity-driven systemic and myocardial inflammation and the mechanistic role of inflammation in pathological myocardial remodeling in HFpEF.

Funder

Foundation for the National Institutes of Health

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiol.00004.2023

Reference198 articles.

1. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019