The Regulation and Physiology of Mitochondrial Proton Leak-Reference-Cited by-同舟云学术

The Regulation and Physiology of Mitochondrial Proton Leak

Published:2011-06 Issue:3 Volume:26 Page:192-205
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Divakaruni Ajit S.¹²,Brand Martin D.¹²

Affiliation:

1. Medical Research Council Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge, United Kingdom; and

2. Buck Institute for Research on Aging, Novato, California

Abstract

Mitochondria couple respiration to ATP synthesis through an electrochemical proton gradient. Proton leak across the inner membrane allows adjustment of the coupling efficiency. The aim of this review is threefold: 1) introduce the unfamiliar reader to proton leak and its physiological significance, 2) review the role and regulation of uncoupling proteins, and 3) outline the prospects of proton leak as an avenue to treat obesity, diabetes, and age-related disease.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00046.2010

Reference231 articles.

1. Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy

2. Absence of mitochondrial uncoupling protein 1 affects apoptosis in thymocytes, thymocyte/T-cell profile and peripheral T-cell number

3. Stronger control of ATP/ADP by proton leak in pancreatic β-cells than skeletal muscle mitochondria

4. On the role of uncoupling protein-2 in pancreatic beta cells

5. Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion

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