ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases-Reference-Cited by-同舟云学术

ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases

Published:2015-11 Issue:6 Volume:30 Page:449-459
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Abdelhamid Ramy E.¹,Sluka Kathleen A.¹

Affiliation:

1. Department of Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, Iowa

Abstract

Chronic musculoskeletal pain is debilitating and affects ∼20% of adults. Tissue acidosis is present in painful musculoskeletal diseases like rheumatoid arthritis. ASICs are located on skeletal muscle and joint nociceptors as well as on nonneuronal cells in the muscles and joints, where they mediate nociception. This review discusses the properties of different types of ASICs, factors affecting their pH sensitivity, and their role in musculoskeletal hyperalgesia and inflammation.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00030.2015

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