Collective Cell Migration: A Mechanistic Perspective

Author:

Vedula Sri Ram Krishna1,Ravasio Andrea1,Lim Chwee Teck12,Ladoux Benoit13

Affiliation:

1. Mechanobiology Institute, National University of Singapore, Singapore;

2. Department of Bioengineering and Department of Mechanical Engineering, National University of Singapore, Singapore; and

3. Institut Jacques Monod, Université Paris Diderot, Paris, France

Abstract

Collective cell migration is fundamental to gaining insights into various important biological processes such as wound healing and cancer metastasis. In particular, recent in vitro studies and in silico simulations suggest that mechanics can explain the social behavior of multicellular clusters to a large extent with minimal knowledge of various cellular signaling pathways. These results suggest that a mechanistic perspective is necessary for a comprehensive and holistic understanding of collective cell migration, and this review aims to provide a broad overview of such a perspective.

Publisher

American Physiological Society

Subject

Physiology

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