Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain-Reference-Cited by-同舟云学术

Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain

Published:2022-11-01 Issue:6 Volume:37 Page:349-362
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Zhao Lucy¹,Tannenbaum Allen²³,Bakker Erik N. T. P.⁴,Benveniste Helene¹⁵^ORCID

Affiliation:

1. Department of Anesthesiology, Yale School of Medicine, New Haven, Connecticut

2. Departments of Computer Science and Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York

3. Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York City, New York

4. Department of Biomedical Engineering and Physics, Amsterdam UMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands

5. Department of Biomedical Engineering, Yale School of Medicine, New Haven, Connecticut

Abstract

This review focuses on the physiology of glymphatic solute transport and waste clearance, using evidence from experimental animal models as well as from human studies. Specific topics addressed include the biophysical characteristics of fluid and solute transport in the central nervous system, glymphatic-lymphatic coupling, as well as the role of cerebrospinal fluid movement for brain waste clearance. We also discuss the current understanding of mechanisms underlying increased waste clearance during sleep.

Funder

Cure Alzheimer's Fund

Fondation Leducq

HHS | NIH | National Center for Complementary and Integrative Health

HHS | NIH | National Institute on Aging

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiol.00015.2022

Reference131 articles.