Ketamine disrupts gaze patterns during face viewing in the common marmoset-Reference-Cited by-全球学者库

Ketamine disrupts gaze patterns during face viewing in the common marmoset

Published:2021-07-01 Issue:1 Volume:126 Page:330-339
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Selvanayagam Janahan¹²^ORCID,Johnston Kevin D.³²,Wong Raymond K.¹²^ORCID,Schaeffer David⁴,Everling Stefan¹³²

Affiliation:

1. Graduate Program in Neuroscience, Western University, London, Ontario, Canada

2. Center for Functional and Metabolic Mapping, Robarts Research Institute, Western University, London, Ontario, Canada

3. Department of Physiology and Pharmacology, Western University, London, Ontario, Canada

4. Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania

Abstract

Face processing, an important social cognitive ability, is impaired in neuropsychiatric conditions such as schizophrenia. The highly social common marmoset model presents an opportunity to investigate these impairments. We administered subanesthetic doses of ketamine to marmosets to model the cognitive symptoms of schizophrenia. We observed a disruption of scan paths during viewing of conspecifics’ faces. These findings support the use of ketamine in marmosets as a model for investigating social cognition in neuropsychiatric disorders.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00078.2021

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