Spinal cord injury significantly alters the properties of reticulospinal neurons: delayed repolarization mediated by potassium channels

Author:

Hough Ryan A.1,McClellan Andrew D.12ORCID

Affiliation:

1. Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States

2. Interdisciplinary Neuroscience Program, University of Missouri, Columbia, Missouri, United States

Abstract

After spinal cord injury (SCI), lamprey reticulospinal (RS) neurons responded to subthreshold depolarizing current pulses with a transient depolarization, which included an initial depolarization that was due to passive channels followed by a delayed repolarization that was mediated by voltage-gated potassium channels. The conductance of these channels ( gK) was significantly increased for RS neurons after SCI and contributed to a reduction in excitability, which is expected to provide supportive conditions for subsequent axonal regeneration.

Funder

American Paralysis Association

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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