Abstract
This review summarizes the mechanisms of cellular cholesterol transport and monogenic human diseases caused by defects in intracellular cholesterol processing. In addition, selected mouse models of disturbed cholesterol trafficking are discussed. Current pharmacological strategies to prevent atherosclerosis are largely based on altering cellular cholesterol balance and are introduced in this context. Finally, because of the organizing potential of cholesterol in membranes, disturbances in cellular cholesterol transport have implications for a wide variety of human diseases, of which selected examples are given.
Publisher
American Physiological Society
Subject
Physiology (medical),Molecular Biology,Physiology,General Medicine
Reference278 articles.
1. Neuronal membrane cholesterol loss enhances amyloid peptide generation
2. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
3. Abildayeva K, Jansen PJ, Hirsch-Reinshagen V, Bloks VW, Bakker AH, Ramaekers FC, De Vente J, Groen AK, Wellington CL, Kuipers F, and Mulder M.24(S)-Hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates Apolipoprotein E-mediated cholesterol efflux.J Biol Chem.In press.
4. ABCA1-Deficient Mice
5. Give lipids a START: the StAR-related lipid transfer (START) domain in mammals
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