Intranasal orexin A modulates sympathetic vascular tone: a pilot study in healthy male humans-Reference-Cited by-全球学者库

Intranasal orexin A modulates sympathetic vascular tone: a pilot study in healthy male humans

Published:2022-02-01 Issue:2 Volume:127 Page:548-558
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Meusel M.¹^ORCID,Voß J.²,Krapalis A.²,Machleidt F.³^ORCID,Vonthein R.⁴^ORCID,Hallschmid M.⁵⁶⁷^ORCID,Sayk F.²^ORCID

Affiliation:

1. Department of Internal Medicine II, University Heart Center Lübeck, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany

2. Department of Internal Medicine I, Universitätsklinikum of Schleswig-Holstein, Lübeck, Germany

3. Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany

4. Institute for Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany

5. Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany

6. German Center for Diabetes Research (DZD), München-Neuherberg, Germany

7. Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Tübingen, Germany

Abstract

Our pilot study adds another important part to the complex network of neuroendocrine-sympathetic interaction. Our results demonstrate that intranasal orexin A elicits an excitatory effect on sympathetic vascular tone superordinate to mere baroreflex feedback regulation. This resetting of the baroreflex set point suggests an activation of hypothalamic core centers such as the paraventricular nucleus (PVN). The role of the orexinergic system in the development of neurogenic arterial hypertension warrants further investigations.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00452.2021

Reference55 articles.

1. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

2. Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

3. Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord