Strain-dependent lung transcriptomic differences in cigarette smoke and LPS models of lung injury in mice-Reference-Cited by-同舟云学术

Strain-dependent lung transcriptomic differences in cigarette smoke and LPS models of lung injury in mice

Published:2023-06-01 Issue:6 Volume:55 Page:259-274
ISSN:1094-8341
Container-title:Physiological Genomics
language:en
Short-container-title:Physiological Genomics

Author:

Siamwala Jamila H.¹^ORCID,Mossman Jim A.²^ORCID,Schorl Christoph³^ORCID,Borgas Diana¹,Sakhatskyy Pavlo¹,Rand David M.²^ORCID,Lu Qing¹,Rounds Sharon¹^ORCID

Affiliation:

1. Vascular Research Laboratory, Veterans Affairs Providence Health Care System, Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States

2. Department of Ecology, Evolution, and Organismal Biology, Brown University, Providence, Rhode Island, United States

3. Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, United States

Abstract

We demonstrate that transcriptomes expressed in lung homogenates also differ between the mouse strains and after acute (3 wk) exposure of animals to cigarette smoke (CS) and/or to lipopolysaccharide. Mouse strains also differed in physiologic, pathologic, and transcriptomic, responses to more prolonged (6 wk) exposure to CS. These data support a genetic basis for enhanced susceptibility to acute and chronic lung injury among humans who smoke cigarettes.

Funder

Brown University

Brown | Warren Alpert Medical School, Brown University

HHS | NIH | National Center for Research Resources

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of General Medical Sciences

National Science Foundation

Rhode Island Foundation

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject