The methylome of buccal epithelial cells is influenced by age, sex, and physiological properties-Reference-Cited by-同舟云学术

The methylome of buccal epithelial cells is influenced by age, sex, and physiological properties

Published:2023-12-01 Issue:12 Volume:55 Page:618-633
ISSN:1094-8341
Container-title:Physiological Genomics
language:en
Short-container-title:Physiological Genomics

Author:

Protti Giulia¹²^ORCID,Rubbi Liudmilla¹,Gören Tarik³,Sabirli Ramazan⁴,Civlan Serkan⁵,Kurt Özgür⁶,Türkçüer İbrahim³,Köseler Aylin⁷,Pellegrini Matteo¹^ORCID

Affiliation:

1. Molecular, Cell and Developmental Biology, University of California, Los Angeles, California, United States

2. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

3. Emergency Department, Pamukkale University Medical Faculty, Denizli, Turkey

4. Emergency Department, Bakircay University Faculty of Medicine Cigli Training and Research Hospital, Izmir, Turkey

5. Department of Neurosurgery, Pamukkale University Faculty of Medicine, Denizli, Turkey

6. Department of Microbiology, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey

7. Department of Biophysics, Pamukkale University Faculty of Medicine, Denizli, Turkey

Abstract

We have developed a quantitative model to assess how the human methylome is associated with several factors and to identify the genomic loci significantly impacted by each trait. We reported novel health-related factors driving DNA methylation patterns and new site-specific regulations that further elucidate methylome dynamics. Our study contributes to a better understanding of the plasticity of the human methylome and unveils novel physiological traits with a potential role in future medical epigenomic investigations.

Publisher

American Physiological Society

Subject

Genetics,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00063.2023

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