Transcriptional response of the heart to vagus nerve stimulation-Reference-Cited by-同舟云学术

Transcriptional response of the heart to vagus nerve stimulation

Published:2024-02-01 Issue:2 Volume:56 Page:167-178
ISSN:1094-8341
Container-title:Physiological Genomics
language:en
Short-container-title:Physiological Genomics

Author:

Kellett Daniel O.¹,Aziz Qadeer¹²,Humphries Jonathan D.³,Korsak Alla¹,Braga Alice¹,Gutierrez Del Arroyo Ana²,Crescente Marilena³,Tinker Andrew²,Ackland Gareth L.²,Gourine Alexander V.¹^ORCID

Affiliation:

1. Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom

2. Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom

3. Department of Life Sciences, Manchester Metropolitan University, Manchester, United Kingdom

Abstract

This experimental animal study investigated the immediate transcriptional response of the ventricular myocardium to selective stimulation of vagal efferent activity. Vagal stimulation induced significant transcriptional changes in the heart involving the pathways controlling autonomic signaling, inflammation, fibrosis, and hypertrophy. This study provides the first direct evidence that myocardial gene expression is modulated by the activity of the autonomic nervous system.

Funder

British Heart Foundation

Publisher

American Physiological Society

Subject

Genetics,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00095.2023

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