Predictive modeling of oocyte maternal mRNA features for five mammalian species reveals potential shared and species-restricted regulators during maturation

Author:

Schall Peter Z.123ORCID,Latham Keith E.124ORCID

Affiliation:

1. Department of Animal Science, Michigan State University, East Lansing, Michigan, United States

2. Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan, United States

3. Comparative Medicine and Integrative Biology Program, Michigan State University, East Lansing, Michigan, United States

4. Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, Michigan, United States

Abstract

Conservation across species of mRNA features regulating maternal mRNA stability during mammalian oocyte maturation was analyzed. 3′-Untranslated region length and synonymous codon usage are positively associated with stability, while GC content is negatively associated. Just three RNA binding protein motifs were predicted to regulate mRNA stability across all five species examined, but associated pathways and functions are shared, indicating oocytes of different species arrive at comparable physiological destinations via different routes.

Funder

AgBioResearch, Michigan State University

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Michigan State University

Publisher

American Physiological Society

Subject

Genetics,Physiology

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